Fine together

Can you use niacinamide and retinol together?

Updated 5 October 2026

Niacinamide and retinol are one of the easiest pairings to use. Niacinamide doesn't interfere with retinol, and many retinol products already include it.

Why they work together

Retinol is the one that tends to irritate. Niacinamide is generally gentle and supports the skin barrier, and some studies suggest niacinamide-based moisturisers can make retinoids easier to tolerate.

How to layer them

There's no strict order. A common approach is niacinamide serum, then retinol, then moisturiser — or retinol followed by a moisturiser that already contains niacinamide.

The usual retinol habits still apply: start two or three nights a week, build up slowly, and wear sunscreen every day.

One caveat

Niacinamide makes retinol easier, not risk-free. If your skin is red and flaky, the answer is less retinol, not more niacinamide.

Common questions

Can I use niacinamide and retinol together?
Yes. It's one of the gentlest pairings, and many retinol products already contain niacinamide.
Should niacinamide go before or after retinol?
Either works. Niacinamide serum then retinol, or retinol then a moisturiser containing niacinamide, are both common.
Can I use niacinamide every day with retinol?
Niacinamide is generally fine daily. The retinol is the one to build up slowly, starting two or three nights a week.

Popular examples

The most-discussed products in each category, with Australian prices.

General information, not medical advice. For a skin condition, or anything prescribed, talk to your GP, pharmacist or a dermatologist.